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British intelligence agent Hattie Shaw intercepts a deadly virus capable of destroying millions of people, but her group is ambushed by cybernetically superior anarchist Brixton. To protect the virus from falling into the hands of the villain, Cathy injects it into her own body, and now she has only 72 hours to find an antidote and save humanity from a biological threat. Special agent Luke Hobbs and his Nemesis and rival Deckard Shaw receive information about what happened, but this time they will have to put their differences aside, because at stake are the fate of millions of people and the life of Deckard's sister...

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